In vivo microstructural heterogeneity of white matter and cognitive correlates in aging using tissue compositional analysis of diffusion magnetic resonance imaging.

ABSTRACT:

Background

Age-related cognitive decline is linked to changes in the brain, particularly the deterioration of white matter (WM) microstructure that accelerates after the age of 60. WM deterioration is associated with mild cognitive impairment and dementia, but the origin and role of white matter signal abnormalities (WMSA) seen in standard MRI remain debated due to their heterogeneity. This study explores the potential of single-shell 3-tissue constrained spherical deconvolution (SS3T-CSD), a novel technique that models diffusion data in terms of gray matter (T_G ), white matter (T_w ), and cerebrospinal fluid (T_C ), to differentiate WMSA from normal-appearing white matter and better understand the interplay between changes in WM microstructure and de

SUBMITTER: Badji A 

PROVIDER: S-EPMC10899800 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature