BTF3L4 Overexpression Mediates APAP-induced Liver Injury in Mouse and Cellular Models.

ABSTRACT:

Background and aims

Acetaminophen (APAP)-induced liver injury (AILI) has an increasing incidence worldwide. However, the mechanisms contributing to such liver injury are largely unknown and no targeted therapy is currently available. The study aimed to investigate the effect of BTF3L4 overexpression on apoptosis and inflammation regulation in vitro and in vivo.

Methods

We performed a proteomic analysis of the AILI model and found basic transcription factor 3 like 4 (BTF3L4) was the only outlier transcription factor overexpressed in the AILI model in mice. BTF3L4 overexpression increased the degree of liver injury in the AILI model.

Results

BTF3L4 exerts its pathogenic effect by inducing an inflammatory response and damaging mitochondrial function. Increa

SUBMITTER: Lin J 

PROVIDER: S-EPMC10899873 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature