Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease.

ABSTRACT:

Background

Coeliac disease (CeD) has been associated with a broad range of diseases in observational data; however, whether these associations are causal remains undetermined. We conducted a phenome-wide Mendelian randomization analysis (MR-PheWAS) to investigate the comorbidities of CeD.

Methods

Single nucleotide polymorphisms (SNPs) associated with CeD at the genome-wide significance threshold and without linkage disequilibrium (R² <0.001) were selected from a genome-wide association study including 12,041 CeD cases as the instrumental variables. We first constructed a polygenic risk score for CeD and estimated its associations with 1060 unique clinical outcomes in the UK Biobank study (N = 385,917). We then used two-sample MR analysis to replicate the identifie

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10900254 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature