GPCR-BERT: Interpreting Sequential Design of G Protein-Coupled Receptors Using Protein Language Models.

ABSTRACT: With the rise of transformers and large language models (LLMs) in chemistry and biology, new avenues for the design and understanding of therapeutics have been opened up to the scientific community. Protein sequences can be modeled as language and can take advantage of recent advances in LLMs, specifically with the abundance of our access to the protein sequence data sets. In this letter, we developed the GPCR-BERT model for understanding the sequential design of G protein-coupled receptors (GPCRs). GPCRs are the target of over one-third of Food and Drug Administration-approved pharmaceuticals. However, there is a lack of comprehensive understanding regarding the relationship among amino acid sequence, ligand selectivity, and conformational motifs (such as NPxxY, CWxP, and E/DRY). By utili

SUBMITTER: Kim S 

PROVIDER: S-EPMC10900288 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature