An evaluation of the combination effect of zoledronate and chemotherapeutic agents in canine osteosarcoma cells.

ABSTRACT:

Introduction

Osteosarcoma (OSA) is an aggressive form of bone cancer in both dogs and humans. The treatment options for metastatic (stage III) OSA are currently limited and the prognosis is poor. Zoledronate, a second generation amino-bisphosphonate, is commonly used for palliation of cancer induced bone pain. Zoledronate has also demonstrated anti-cancer properties and possibly enhances the cytotoxicity of doxorubicin in a canine histiocytosis cell line and human prostatic cancer cell line. The goal of this study was to evaluate the combination effect of zoledronate and various chemotherapeutic drugs in canine OSA cells.

Methods

Canine OSA cell line (D17), cells from two canine primary OSAs, and MDCK, a canine kidney cell line, were used to evaluate the therapeutic potentia

SUBMITTER: Iwaki Y 

PROVIDER: S-EPMC10900512 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature