Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve.

ABSTRACT:

Background

Impaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia. The smallness and intricate architecture of the optic nerve subarachnoid space (ONSAS) hamper accurate measurements of CSF dynamics in this space, and effects of geometrical changes due to pathophysiological processes remain unclear. The aim of this study is to investigate CSF dynamics and its response to structural alterations of the ONSAS, from first principles, with supercomputers.

Methods

Large-scale in-silico investigations were performed by means of computational fluid dynamics (CFD) analysis. High-order direct num

SUBMITTER: Rossinelli D 

PROVIDER: S-EPMC10900650 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature