Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis.

ABSTRACT:

Purpose

Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all pairwise and higher-order interactions requires significant computational resources. Furthermore, existing methods for epistasis detection only consider a Cartesian (multiplicative) model for interaction terms. This is likely limiting as epistatic interactions can evolve to produce varied relationships between genetic loci, some complex and not linearly separable.

Methods

We present new algorithms for the interaction coefficients for standard regression models for epistasis that permit many varied models for the interaction

SUBMITTER: Batista S 

PROVIDER: S-EPMC10900690 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature