ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis.

ABSTRACT:

Background

Diabetic nephropathy (DN) and atherosclerosis (AS) are prevalent and severe complications associated with diabetes, exhibiting lesions in the basement membrane, an essential component found within the glomerulus, tubules, and arteries. These lesions contribute significantly to the progression of both diseases, however, the precise underlying mechanisms, as well as any potential shared pathogenic processes between them, remain elusive.

Methods

Our study analyzed transcriptomic profiles from DN and AS patients, sourced from the Gene Expression Omnibus database. A combination of integrated bioinformatics approaches and machine learning models were deployed to identify crucial genes connected to basement membrane lesions in both conditions. The role of integrin subuni

SUBMITTER: Lou Y 

PROVIDER: S-EPMC10900706 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature