Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.

ABSTRACT:

Background

Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell's immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary signaling can lead to ciliopathies and certain neurodevelopmental disorders. In the developing brain cilia play well-documented roles for the expansion of the neural progenitor cell pool, while information about the roles of cilia during post-mitotic neuron differentiation and maturation is scarce.

Results

We employed ciliated Lund Human Mesencephalic (LUHMES) cells in time course experiments to assess the impact of ciliary signaling on neuron differentiation. By comparing ciliated and non-ciliated neuronal precursor cells and neurons in

SUBMITTER: Coschiera A 

PROVIDER: S-EPMC10900739 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature