Mammary epithelium permeability during established lactation: associations with cytokine levels in human milk.

ABSTRACT:

Objective

The cytokine profile of human milk may be a key indicator of mammary gland health and has been linked to infant nutrition, growth, and immune system development. The current study examines the extent to which mammary epithelium permeability (MEP) is associated with cytokine profiles during established lactation within a sample of US mothers.

Methods

Participants were drawn from a previous study of human milk cytokines. The present analysis includes 162 participants (98 Black, 64 White) with infants ranging from 1 to 18 months of age. Levels of cytokines were determined previously. Here we measure milk sodium (Na) and potassium (K) levels with ion-selective probes. Two approaches were used to define elevated MEP: Na levels ≥10 mmol/L and Na/K ratios greater t

SUBMITTER: Kivlighan KT 

PROVIDER: S-EPMC10900798 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature