MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation.

ABSTRACT: Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative treatment available, and liver transplantation is inevitable for end-stage patients. Human placental mesenchymal stem cell (hpMSC)-derived exosomes have demonstrated the ability to prevent fibrosis, inhibit collagen production and possess immunomodulatory properties in autoimmune liver disease. Here, we prepared hpMSC-derived exosomes (Exo^MSC) and further investigated the anti-fibrotic effects and detailed mechanism on PSC based on Mdr2^-/- mice and multicellular organoids established from PSC patients. The results showed that Exo^MSC ameliorated liver fibrosis in Mdr2^-/- mice

SUBMITTER: Chen W 

PROVIDER: S-EPMC10900800 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature