Antibiotic dosing recommendations in critically ill patients receiving new innovative kidney replacement therapy.

ABSTRACT:

Background

The Tablo Hemodialysis System is a new innovative kidney replacement therapy (KRT) providing a range of options for critically ill patients with acute kidney injury. The use of various effluent rate and treatment durations/frequencies may clear antibiotics differently than traditional KRT. This Monte Carlo Simulation (MCS) study was to develop antibiotic doses likely to attain therapeutic targets for various KRT combinations.

Methods

Published body weights and pharmacokinetic parameter estimates were used to predict drug exposure for cefepime, ceftazidime, imipenem, meropenem and piperacillin/tazobactam in virtual critically ill patients receiving five KRT regimens. Standard free β-lactam plasma concentration time above minimum inhibitory concentration targets (40

SUBMITTER: Lewis SJ 

PROVIDER: S-EPMC10900833 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature