Sjogren's Disease and Oral Health: A Genetic Instrumental Variable Analysis.

ABSTRACT: Epidemiological studies have consistently shown that Sjögren's disease (SjD) increases the risk of dental caries. Despite similar evidence indicating an elevated risk of periodontitis, SjD remains a disputed risk factor for this disease. The risk of bias in observational research is a major impediment to confirming this link. Within an instrumental variable framework, genetic variants associated with a risk factor can be used to proxy its effect on an outcome while avoiding common sources of observational study bias. In this study, we leveraged an instrumental variable approach to investigate whether SjD affects the risk of caries and periodontitis. A total of 57 genetic variants strongly associated with SjD were identified from a genome-wide association study of 2,247 European descent cas

SUBMITTER: Reckelkamm SL 

PROVIDER: S-EPMC10900855 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature