Genetic testing for hereditary cancer syndromes in Tunisian patients: Impact on health system.

ABSTRACT:

Introduction

Cancer management in Africa faces diverse challenges due to limited resources, health system challenges, and other matters. Identifying hereditary cancer syndromic cases is crucial to improve clinical management and preventive care in these settings. This study aims to explore the clinicopathological features and genetic factors associated with hereditary cancer in Tunisia, a North African country with a rising cancer burden MATERIALS AND METHODS: Clinicopathological features and personal/family history of cancer were explored in 521 patients. Genetic analysis using Sanger and next-generation sequencing was performed for a set of patients RESULTS: Hereditary breast and ovarian cancer syndrome was the most frequent cluster in which 36 BRCA mutations were identified. We

SUBMITTER: Jandoubi N 

PROVIDER: S-EPMC10900923 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature