Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier.

ABSTRACT:

Background

The reclassification of Papillary Thyroid Carcinoma (PTC) is an area of research that warrants attention. The connection between thyroid cancer, inflammation, and immune responses necessitates considering the mechanisms of differential prognosis of thyroid tumors from an immunological perspective. Given the high adaptability of macrophages to environmental stimuli, focusing on the differentiation characteristics of macrophages might offer a novel approach to address the issues related to PTC subtyping.

Methods

Single-cell RNA sequencing data of medullary cells infiltrated by papillary thyroid carcinoma obtained from public databases was subjected to dimensionality reduction clustering analysis. The RunUMAP and FindAllMarkers functions were utilized to identify the

SUBMITTER: Sun H 

PROVIDER: S-EPMC10900934 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature