The global landscape of immune-derived lncRNA signature in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a highly heterogeneous cancer. This heterogeneity has an impact on the efficacy of immunotherapy. Long noncoding RNAs (lncRNAs) have been found to play regulatory functions in cancer immunity. However, the global landscape of immune-derived lncRNA signatures has not yet been explored in colorectal cancer.

Methods

In this study, we applied DESeq2 to identify differentially expressed lncRNAs in colon cancer. Next, we performed an integrative analysis to globally identify immune-driven lncRNA markers in CRC, including immune-associated pathways, tumor immunogenomic features, tumor-infiltrating immune cells, immune checkpoints, microsatellite instability (MSI) and tumor mutation burden (TMB).

Results

We also identified dysregulated ln

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10900961 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature