Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank.

ABSTRACT:

Importance

Candidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable to diet may differ according to genotype. A genome-wide approach further allows for the exploration of underlying pathways for associations between diet and CRC risk across the genome.

Objectives

To identify genetic variants that modify diet-CRC associations and to further explore the underlying pathways in the cause of CRC.

Design, setting, and participants

This nested case-control study used data on White British participants from the prospective cohort UK Biobank. Participants were recruited between March 13, 2006, and October 1, 2010, and data were censored June 25, 2021.

Exposures

The average frequency intake of 11 dietary factors in the year preceding b

SUBMITTER: Hoang T 

PROVIDER: S-EPMC10900970 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature