Automated analysis of gray matter damage in aged mice reveals impaired remyelination in the cuprizone model.

ABSTRACT: Multiple sclerosis is a chronic autoimmune disease of the central nervous system characterized by myelin loss, axonal damage, and glial scar formation. Still, the underlying processes remain unclear, as numerous pathways and factors have been found to be involved in the development and progression of the disease. Therefore, it is of great importance to find suitable animal models as well as reliable methods for their precise and reproducible analysis. Here, we describe the impact of demyelination on clinically relevant gray matter regions of the hippocampus and cerebral cortex, using the previously established cuprizone model for aged mice. We could show that bioinformatic image analysis methods are not only suitable for quantification of cell populations, but also for the assessment of de

SUBMITTER: Gingele S 

PROVIDER: S-EPMC10901622 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature