Circulating myeloid-derived MMP8 in stress susceptibility and depression.

ABSTRACT: Psychosocial stress has profound effects on the body, including the immune system and the brain^1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)³, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of

SUBMITTER: Cathomas F 

PROVIDER: S-EPMC10901735 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature