Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction.

ABSTRACT: With the advent of increasingly sophisticated organoids, there is growing demand for technology to replicate the interactions between multiple tissues or organs. This is challenging to achieve, however, due to the varying culture conditions of the different cell types that make up each tissue. Current methods often require complicated microfluidic setups, but fragile tissue samples tend not to fare well with rough handling. Furthermore, the more complicated the human system to be replicated, the more difficult the model becomes to operate. Here, we present the development of a multi-tissue chip platform that takes advantage of the modularity and convenient handling ability of a CUBE device. We first developed a blood-brain barrier-in-a-CUBE by layering astrocytes, pericytes, and brain micr

SUBMITTER: Koh I 

PROVIDER: S-EPMC10901775 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature