Cortical bone adaptation response is region specific, but not peak load dependent: insights from μ CT image analysis and mechanostat simulations of the mouse tibia loading model.

ABSTRACT: The two major aims of the present study were: (i) quantify localised cortical bone adaptation at the surface level using contralateral endpoint imaging data and image analysis techniques, and (ii) investigate whether cortical bone adaptation responses are universal or region specific and dependent on the respective peak load. For this purpose, we re-analyse previously published μ CT data of the mouse tibia loading model that investigated bone adaptation in response to sciatic neurectomy and various peak load magnitudes (F = 0, 2, 4, 6, 8, 10, 12 N). A beam theory-based approach was developed to simulate cortical bone adaptation in different sections of the tibia, using longitudinal strains as the adaptive stimuli. We developed four mechanostat models: universal, surface-based, strain direc

SUBMITTER: Miller CJ 

PROVIDER: S-EPMC10901956 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature