Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease.

ABSTRACT:

Background

Vulnerable plaque was associated with recurrent cardiovascular events. This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease.

Methods

To reveal the phenotype-associated cell type in the development of vulnerable plaque and to identify hub gene for pathological process, we combined single-cell RNA and bulk RNA sequencing datasets of human atherosclerotic plaques using Single-Cell Identification of Subpopulations with Bulk Sample Phenotype Correlation (Scissor) and Weighted gene co-expression network analysis (WGCNA). We also validated our results in an independent cohort of patients by using intravascular ultrasound during coronary angiography.

Results

Macrophages were found to be strongly corr

SUBMITTER: Huang K 

PROVIDER: S-EPMC10902157 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature