Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial.

ABSTRACT:

Background

Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain. The objectives of this study were to estimate the proportion of patients achieving LDP targets in different modes of ventilation, and to identify predictors of need for extracorporeal carbon dioxide removal (ECCO₂R) to achieve LDP targets.

Methods

An in silico clinical trial was conducted using a previously published mathematical model of patient-ventilator interaction in a simulated patient population (n = 5000) with clinically relevant physiological characteristics. Ventilation and sedation were titrated according to a pre-defined algorithm in pressure support ventilation (PSV

SUBMITTER: Ratano D 

PROVIDER: S-EPMC10902250 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature