Id2 epigenetically controls CD8⁺ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex.

ABSTRACT: CD8⁺ T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6⁺ progenitor exhausted (Tex^prog) and Tim-3⁺ terminally exhausted (Tex^term) subpopulations. Inhibitor of DNA binding protein 2 (Id2) has been shown to play important roles in T-cell development and CD8⁺ T-cell immunity. However, the role of Id2 in CD8⁺ T-cell exhaustion is unclear. Here, we found that Id2 transcriptionally and epigenetically regulates the generation of Tex^prog cells and their conversion to Tex^term cells. Genetic deletion of Id2 dampens CD8⁺ T-cell-mediated immune responses and the maintenance of stem-like CD8⁺ T-cell subpopulations, su

SUBMITTER: Li Y 

PROVIDER: S-EPMC10902300 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature