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Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.

ABSTRACT: A key limitation of current dynamic contrast enhanced (DCE) MRI techniques is the requirement for full-dose gadolinium-based contrast agent (GBCA) administration. The purpose of this feasibility study was to develop and assess a new low GBCA dose protocol for deriving high-spatial resolution kinetic parameters from brain DCE-MRI. Nineteen patients with intracranial skull base tumours were prospectively imaged at 1.5 T using a single-injection, fixed-volume low GBCA dose, dual temporal resolution interleaved DCE-MRI acquisition. The accuracy of kinetic parameters (v_e, K^trans, v_p) derived using this new low GBCA dose technique was evaluated through both Monte-Carlo simulations (mean percent deviation, PD, of measured from true values) and an in vivo study incorporating comparison with a conventional full-dose GBCA protocol and correlation with histopathological data. The mean PD of data from the interleaved high-temporal-high-spatial resolution approach outperformed use of high-spatial, low temporal resolution datasets alone (p < 0.0001, t-test). Kinetic parameters derived using the low-dose interleaved protocol correlated significantly with parameters derived from a full-dose acquisition (p < 0.001) and demonstrated a significant association with tissue markers of microvessel density (p < 0.05). Our results suggest accurate high-spatial resolution kinetic parameter mapping is feasible with significantly reduced GBCA dose.

SUBMITTER: Lewis D

PROVIDER: S-EPMC10902320 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.

Lewis Daniel D Li Ka-Loh KL Waqar Mueez M Coope David J DJ Pathmanaban Omar N ON King Andrew T AT Djoukhadar Ibrahim I Zhao Sha S Cootes Timothy F TF Jackson Alan A Zhu Xiaoping X

Scientific reports 20240228 1

A key limitation of current dynamic contrast enhanced (DCE) MRI techniques is the requirement for full-dose gadolinium-based contrast agent (GBCA) administration. The purpose of this feasibility study was to develop and assess a new low GBCA dose protocol for deriving high-spatial resolution kinetic parameters from brain DCE-MRI. Nineteen patients with intracranial skull base tumours were prospectively imaged at 1.5 T using a single-injection, fixed-volume low GBCA dose, dual temporal resolution ...[more]

PMID: 38418818

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Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.

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Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.

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