A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation.

ABSTRACT: RNA modifications have emerged as central regulators of gene expression programs. Amongst RNA modifications are N6-methyladenosine (m⁶A) and RNA 5-hydroxymethylcytosine (5hmC). While m⁶A is established as a versatile regulator of RNA metabolism, the functions of RNA 5hmC are unclear. Despite some evidence linking RNA modifications to immunity, their implications in gene expression control in macrophage development and functions remain unclear. Here we present a multi-omics dataset capturing different layers of the gene expression programs driving macrophage differentiation and polarisation. We obtained mRNA-Seq, m⁶A-IP-Seq, 5hmC-IP-Seq, Polyribo-Seq and LC-MS/MS data from monocytes and resting-, pro- and anti-inflammatory-like macrophages. We present techni

SUBMITTER: Pinello N 

PROVIDER: S-EPMC10902381 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature