Development of a promising PPAR signaling pathway-related prognostic prediction model for hepatocellular carcinoma.

ABSTRACT: The peroxisome proliferator-activated receptor (PPAR) signaling pathway plays a crucial role in systemic cell metabolism, energy homeostasis and immune response inhibition. However, its significance in hepatocellular carcinoma (HCC) has not been well documented. In our study, based on the RNA sequencing data of HCC, consensus clustering analyses were performed to identify PPAR signaling pathway-related molecular subtypes, each of which displaying varying survival probabilities and immune infiltration status. Following, a prognostic prediction model of HCC was developed by using the random survival forest method and Cox regression analysis. Significant difference in survival outcome, immune landscape, drug sensitivity and pathological features were observed between patients with different p

SUBMITTER: Shi Q 

PROVIDER: S-EPMC10902383 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature