Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm.

ABSTRACT: Prior research has identified epigenetic predictors of attention problems in school-aged children but has not yet investigated these in young children, or children at elevated risk of attention problems due to preterm birth. The current study evaluated epigenome-wide associations between neonatal DNA methylation and attention problems at age 2 years in children born very preterm. Participants included 441 children from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study, a multi-site study of infants born < 30 weeks gestational age. DNA methylation was measured from buccal swabs collected at NICU discharge using the Illumina MethylationEPIC Bead Array. Attention problems were assessed at 2 years of adjusted age using the attention problems subscale of the Child Beh

SUBMITTER: Camerota M 

PROVIDER: S-EPMC10902402 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature