Modeling bacterial microcompartment architectures for enhanced cyanobacterial carbon fixation.

ABSTRACT: The carboxysome is a bacterial microcompartment (BMC) which plays a central role in the cyanobacterial CO₂-concentrating mechanism. These proteinaceous structures consist of an outer protein shell that partitions Rubisco and carbonic anhydrase from the rest of the cytosol, thereby providing a favorable microenvironment that enhances carbon fixation. The modular nature of carboxysomal architectures makes them attractive for a variety of biotechnological applications such as carbon capture and utilization. In silico approaches, such as molecular dynamics (MD) simulations, can support future carboxysome redesign efforts by providing new spatio-temporal insights on their structure and function beyond in vivo experimental limitations. However, specific computational stu

SUBMITTER: Trettel DS 

PROVIDER: S-EPMC10902431 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature