Genomic and ecological approaches to identify the Bifidobacterium breve prototype of the healthy human gut microbiota.

ABSTRACT: Members of the genus Bifidobacterium are among the first microorganisms colonizing the human gut. Among these species, strains of Bifidobacterium breve are known to be commonly transmitted from mother to her newborn, while this species has also been linked with activities supporting human wellbeing. In the current study, an in silico approach, guided by ecology- and phylogenome-based analyses, was employed to identify a representative strain of B. breve to be exploited as a novel health-promoting candidate. The selected strain, i.e., B. breve PRL2012, was found to well represent the genetic content and functional genomic features of the B. breve taxon. We evaluated the ability of PRL2012 to survive in the gastrointestinal tract and to interact with

SUBMITTER: Argentini C 

PROVIDER: S-EPMC10902438 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature