Investigating causal associations among gut microbiota, metabolites, and psoriatic arthritis: a Mendelian randomization study.

ABSTRACT:

Background

Currently, there has been observed a significant alteration in the composition of the gut microbiome (GM) and serum metabolites in patients with psoriatic arthritis (PsA) compared to healthy individuals. However, previous observational studies have shown inconsistent results regarding the alteration of gut microbiota/metabolites. In order to shed light on this matter, we utilized Mendelian randomization to determine the causal effect of GM/metabolites on PsA.

Methods

We retrieved summary-level data of GM taxa/metabolites and PsA from publicly available GWAS statistics. Causal relationships between GM/metabolites and PsA were determined using a two-sample MR analysis, with the IVW approach serving as the primary analysis method. To ensure the robustness of our find

SUBMITTER: Xu X 

PROVIDER: S-EPMC10902440 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature