Glycine is a transmitter in the human and chimpanzee cochlear nuclei.

ABSTRACT:

Introduction

Auditory information is relayed from the cochlea via the eighth cranial nerve to the dorsal and ventral cochlear nuclei (DCN, VCN). The organization, neurochemistry and circuitry of the cochlear nuclei (CN) have been studied in many species. It is well-established that glycine is an inhibitory transmitter in the CN of rodents and cats, with glycinergic cells in the DCN and VCN. There are, however, major differences in the laminar and cellular organization of the DCN between humans (and other primates) and rodents and cats. We therefore asked whether there might also be differences in glycinergic neurotransmission in the CN.

Methods

We studied brainstem sections from humans, chimpanzees, and cats. We used antibodies to glycine receptors (GLYR) to identify neurons

SUBMITTER: Baizer JS 

PROVIDER: S-EPMC10902441 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature