Calreticulin: Endoplasmic reticulum Ca²⁺ gatekeeper.

ABSTRACT: Endoplasmic reticulum (ER) luminal Ca²⁺ is vital for the function of the ER and regulates many cellular processes. Calreticulin is a highly conserved, ER-resident Ca²⁺ binding protein and lectin-like chaperone. Over four decades of studying calreticulin demonstrate that this protein plays a crucial role in maintaining Ca²⁺ supply under different physiological conditions, in managing access to Ca²⁺ and how Ca²⁺ is used depending on the environmental events and in making sure that Ca²⁺ is not misused. Calreticulin plays a role of ER luminal Ca²⁺ sensor to manage Ca²⁺ -dependent ER luminal events including maintaining interaction with its partners, Ca²⁺ handling molecules, substrates and stress

SUBMITTER: Michalak M 

PROVIDER: S-EPMC10902585 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature