Lipotype acquisition during neural development is not recapitulated in stem cell-derived neurons.

ABSTRACT: During development, different tissues acquire distinct lipotypes that are coupled to tissue function and homeostasis. In the brain, where complex membrane trafficking systems are required for neural function, specific glycerophospholipids, sphingolipids, and cholesterol are highly abundant, and defective lipid metabolism is associated with abnormal neural development and neurodegenerative disease. Notably, the production of specific lipotypes requires appropriate programming of the underlying lipid metabolic machinery during development, but when and how this occurs is unclear. To address this, we used high-resolution MS^ALL lipidomics to generate an extensive time-resolved resource of mouse brain development covering early embryonic and postnatal stages. This revealed a distinct

SUBMITTER: Gopalan AB 

PROVIDER: S-EPMC10902711 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature