Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.

ABSTRACT:

Introduction

Urinary incontinence (UI) is a common and disruptive symptom of Parkinson's disease (PD). This study aimed to identify neural correlates associated with UI among PD patients with UI (UI-PD) compared to those PD patients without UI (nonUI-PD) with the expectation of demonstrating increased functional connectivity (FC) between areas in the striatum and limbic system and decreased FC in executive areas.

Methods

rsfMRI and T1w data (n = 119) were retrieved from the Parkinson's Progression Markers Initiative (PPMI). Resting-state FC analyses assessed temporal covariance with anterior cingulate gyrus, precuneus, and putamen seed regions.

Results

The UI-PD group (n = 32, 16 females) showed significantly greater positive FC between the bilateral putamen seed and

SUBMITTER: Denmon C 

PROVIDER: S-EPMC10902789 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature