Multiplexed near infrared fluorescence lifetime imaging in turbid media.

ABSTRACT:

Significance

Fluorescence lifetime imaging (FLI) plays a pivotal role in enhancing our understanding of biological systems, providing a valuable tool for non-invasive exploration of biomolecular and cellular dynamics, both in vitro and in vivo. Its ability to selectively target and multiplex various entities, alongside heightened sensitivity and specificity, offers rapid and cost-effective insights.

Aim

Our aim is to investigate the multiplexing capabilities of near-infrared (NIR) FLI within a scattering medium that mimics biological tissues. We strive to develop a comprehensive understanding of FLI's potential for multiplexing diverse targets within a complex, tissue-like environment.

Approach

We introduce an innovative Monte Carlo (MC) simulation appro

SUBMITTER: Harel M 

PROVIDER: S-EPMC10902792 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature