Theoretical Examination Seeking Tangible Physical Meanings of Slopes and Intercepts of Plasma Concentration-Time Relationships in Minimal Physiologically Based Pharmacokinetic Models.

ABSTRACT: In minimal physiologically based pharmacokinetic (mPBPK) models, physiological (e.g., cardiac output) and anatomical (e.g., blood/tissue volumes) variables are utilized in the domain of differential equations (DEs) for mechanistic understanding of the plasma concentration-time relationships [Formula: see text]. Although fundamental biopharmaceutical variables in terms of distribution (e.g., [Formula: see text] and [Formula: see text]) and elimination kinetics (e.g., [Formula: see text]) in mPBPK provide greater insights in comparison to classical compartment models, an absence of kinetic elucidation of slopes and intercepts in light of such DE model parameters hinders more intuitive appreciation of [Formula: see text]. Therefore, this study seeks the tangible physical meanings of slopes an

SUBMITTER: Jeong YS 

PROVIDER: S-EPMC10902795 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature