Orthogonal moment diffusion tensor decomposition reveals age-related degeneration patterns in complex fiber architecture.

ABSTRACT: Diffusion tensor imaging (DTI) consistently detects increased mean diffusivity and decreased fractional anisotropy with advancing age in regions of primarily single white matter (WM) fiber populations, but findings have been inconsistent in regions of more complex fiber architecture. Given that DTI remains more common for characterizing aging WM than advanced diffusion MRI models due to DTI's simplicity, robustness, and efficiency, it is critical to strive to maximize the information extracted from DTI across the entire WM. The present study uses an orthogonal diffusion tensor decomposition based on the 3 eigenvalue moments (mean diffusivity, norm of anisotropy, and mode of anisotropy), yielding clear voxelwise degeneration patterns across the WM, including regions of complex fiber archite

SUBMITTER: Chad JA 

PROVIDER: S-EPMC10902820 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature