Interactions and effects of a stannous-containing sodium fluoride dentifrice on oral pathogens and the oral microbiome.

ABSTRACT: Numerous studies have investigated the effects of stannous ions on specific microbes and their efficacy in reducing dental plaque. Nonetheless, our understanding of their impact on the oral microbiome is still a subject of ongoing exploration. Therefore, this study sought to evaluate the effects of a stannous-containing sodium fluoride dentifrice in comparison to a zinc-containing sodium fluoride dentifrice and a control group on intact, healthy oral biofilms. Utilizing the novel 2bRAD-M approach for species-resolved metagenomics, and FISH/CLSM with probes targeting periodontal and caries associated species alongside Sn²⁺ and Zn²⁺ ions, we collected and analyzed in situ biofilms from 15 generally healthy individuals with measurable dental plaque and treated the

SUBMITTER: Chen D 

PROVIDER: S-EPMC10902866 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature