Effects of vasoactive substances on biomechanics of small resistance arteries of male and female Dahl salt-sensitive rats.

ABSTRACT: Changes in vascular biomechanics leading to increase in arterial stiffness play a pivotal role in circulatory dysfunction. Our objectives were to examine sex-specific pharmacological changes related to the biomechanics and any structural modifications in small resistance arteries of Dahl salt-sensitive male and female rats. The composite Young modulus (CYM) was determined using pressure myograph recordings, and immunohistochemistry was used for the evaluation of any structural changes in the third-order mesenteric arteries (n = 6). Animals on high-salt diet developed hypertension with significant elevation in central and peripheral blood pressures and pulse wave velocity compared to those on regular diet. There were no significant differences observed in the CYM between any of the groups (

SUBMITTER: Mensah EA 

PROVIDER: S-EPMC10902908 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature