Bacteroides salyersiae is a potent chondroitin sulfate-degrading species in the human gut microbiota.

ABSTRACT: Chondroitin sulfate (CS) has widely been used as a symptomatic slow-acting drug or a dietary supplement for the treatment and prevention of osteoarthritis. However, CS could not be absorbed after oral intake due to its polyanionic nature and large molecular weight. Gut microbiota has recently been proposed to play a pivotal role in the metabolism of drugs and nutrients. Nonetheless, how CS is degraded by the human gut microbiota has not been fully characterized. In the present study, we demonstrated that each human gut microbiota was characterized with a unique capability for CS degradation. Degradation and fermentation of CS by the human gut microbiota produced significant amounts of unsaturated CS oligosaccharides (CSOSs) and short-chain fatty acids. To uncover which microbes were respon

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10902947 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature