The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target.

ABSTRACT: Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote cancer recurrence, spreading of cancer, and finally, mortality. Accordingly, enhancing the responsiveness of cancer cells towards chemotherapies could be a vital approach to overcoming cancer chemoresistance. Tumour cells express a high level of sphingosine kinase-1 (SphK1), which acts as a protooncogenic factor and is responsible for the synthesis of sphingosine-1 phosphate (S1P). S1P is released through a Human ATP-binding cassette (ABC) transporter to interact with other phosphosphingolipids components in the interstitial fluid in the tumor microenvironment (TME), provoking communication, progression, invasion, and tumor metastasis. Also, S1P is associated wi

SUBMITTER: Alkafaas SS 

PROVIDER: S-EPMC10903003 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature