Temporal gene expression profiling during early-stage traumatic temporomandibular joint bony ankylosis in a sheep model.

ABSTRACT:

Background

Investigating the molecular biology underpinning the early-stage of traumatic temporomandibular joint (TMJ) ankylosis is crucial for discovering new ways to prevent the disease. This study aimed to explore the dynamic changes of transcriptome from the intra-articular hematoma or the newly generated ankylosed callus during the onset and early progression of TMJ ankylosis.

Methods

Based on a well-established sheep model of TMJ bony ankylosis, the genome-wide microarray data were obtained from samples at postoperative Days 1, 4, 7, 9, 11, 14 and 28, with intra-articular hematoma at Day 1 serving as controls. Fold changes in gene expression values were measured, and genes were identified via clustering based on time series analysis and further categorised into three m

SUBMITTER: Zhang TM 

PROVIDER: S-EPMC10903020 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature