Development of finely tuned liposome nanoplatform for macrophage depletion.

ABSTRACT:

Background

Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome^® and m-Clodrosome^®) are limited by their inconsistent size and therapeutic efficacy. Thus, we aimed to achieve consistent therapeutic effects by effectively depleting macrophages with uniform-sized liposomes.

Results

We developed four types of click chemistry-based liposome nanoplatforms that were uniformly sized and encapsulated with clodronate, for effective macrophage depletion, followed by conjugation with Man-N₃ and radiolabeling. Functionalization with Man-N₃ improves the specific targeting of M2 macrophages, and radioisotop

SUBMITTER: Choi TH 

PROVIDER: S-EPMC10903058 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature