Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression.

ABSTRACT:

Background

Small airways disease (SAD) is a major cause of airflow obstruction in COPD patients and has been identified as a precursor to emphysema. Although the amount of SAD in the lungs can be quantified using our Parametric Response Mapping (PRM) approach, the full breadth of this readout as a measure of emphysema and COPD progression has yet to be explored. We evaluated topological features of PRM-derived normal parenchyma and SAD as surrogates of emphysema and predictors of spirometric decline.

Methods

PRM metrics of normal lung (PRM^Norm) and functional SAD (PRM^fSAD) were generated from CT scans collected as part of the COPDGene study (n = 8956). Volume density (V) and Euler-Poincaré Characteristic (χ) image maps, measures of the extent and coales

SUBMITTER: Bell AJ 

PROVIDER: S-EPMC10903150 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature