Novel diagnostic biomarkers related to necroptosis and immune infiltration landscape in acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) can occur suddenly, which may induce deadly outcomes, and the population suffering from AMI presents a younger trend. Necroptosis, the new cell necrosis type, is associated with the pathogenic mechanisms of diverse cardiovascular diseases (CVDs). Its diagnostic value and molecular mechanisms in AMI are still unclear. Objective: This study focused on determining key necroptosis-related genes as well as immune infiltration in AMI.

Methods

We first examined the GSE66360 dataset for identifying necroptosis-related differentially expressed genes (NRDEGs). Thereafter, GO and functional annotation were performed, then a PPI network was built. In addition, "CIBERSORT" in R was applied in comparing different immune infiltration degrees in

SUBMITTER: Wu W 

PROVIDER: S-EPMC10903340 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature