Mathematical modelling of antibiotic interaction on evolution of antibiotic resistance: an analytical approach.

ABSTRACT:

Background

The emergence and spread of antibiotic-resistant pathogens have led to the exploration of antibiotic combinations to enhance clinical effectiveness and counter resistance development. Synergistic and antagonistic interactions between antibiotics can intensify or diminish the combined therapy's impact. Moreover, these interactions can evolve as bacteria transition from wildtype to mutant (resistant) strains. Experimental studies have shown that the antagonistically interacting antibiotics against wildtype bacteria slow down the evolution of resistance. Interestingly, other studies have shown that antibiotics that interact antagonistically against mutants accelerate resistance. However, it is unclear if the beneficial effect of antagonism in the wildtype bacteria is more c

SUBMITTER: Nashebi R 

PROVIDER: S-EPMC10903357 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature