The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms.

ABSTRACT: Numerous bacteria naturally occur within spatially organised, multicellular communities called biofilms. Moreover, most bacterial infections proceed with biofilm formation, posing major challenges to human health. Within biofilms, bacterial cells are embedded in a primarily self-produced extracellular matrix, which is a defining feature of all biofilms. The biofilm matrix is a complex, viscous mixture primarily composed of polymeric substances such as polysaccharides, filamentous protein fibres, and extracellular DNA. The structured arrangement of the matrix bestows bacteria with beneficial emergent properties that are not displayed by planktonic cells, conferring protection against physical and chemical stresses, including antibiotic treatment. However, a lack of multi-scale information a

SUBMITTER: Bohning J 

PROVIDER: S-EPMC10903470 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature