Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study.

ABSTRACT:

Background

An increased risk of neurocognitive deficits, anxiety, and depression has been reported in childhood cancer survivors.

Methods

We analyzed associations of neurocognitive deficits, as well as anxiety and depression, with common and rare genetic variants derived from whole-exome sequencing data of acute lymphoblastic leukemia (ALL) survivors from the PETALE cohort. In addition, significant associations were assessed using stratified and multivariable analyses. Next, top-ranking common associations were analyzed in an independent SJLIFE replication cohort of ALL survivors.

Results

Significant associations were identified in the entire discovery cohort (N = 229) between the AK8 gene and changes in neurocognitive function, whereas PTPRZ1, MUC16, TNRC6C-AS1 were

SUBMITTER: Petrykey K 

PROVIDER: S-EPMC10903523 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature