Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study.

ABSTRACT:

Background

An anthocyanidin, pelargonidin, primarily found in berries, has antioxidant and anti-inflammatory properties, and is associated with better cognition and reduced Alzheimer's dementia risk.

Objective

This study investigated if pelargonidin or berry intake is associated with Alzheimer's disease (AD) neuropathology in human brains.

Methods

The study was conducted among 575 deceased participants (age at death = 91.3±6.1 years; 70% females) of the Rush Memory and Aging Project, with dietary data (assessed using a food frequency questionnaire) and neuropathological evaluations. Calorie-adjusted pelargonidin intake was modeled in quartiles and berry intake as continuous (servings/week). Mean amyloid-beta load and phosphorylated tau neuronal neurofibrillary tangle

SUBMITTER: Agarwal P 

PROVIDER: S-EPMC10903634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature